The special issue of the journal BMJ Medical Humanities co-edited by Dr Gavin Miller and myself has now gone live. It offers strong papers that together showcase the fruitful potential to be found at the interstices of science fiction and the medical humanities. The introduction provides something of a manifesto for what we hope to achieve in this project and beyond, highlighting science fiction’s role in the technoscientific imaginary, while the papers take a wide range of approaches to analyse how that imaginary is constructed with the help of science fiction and science-fictional approaches. Fields covered in the papers include bioethics, speculative design, Afrofuturism, literary analysis, and historical approaches. We would like to thank all of our contributors for their hard work in producing such strong papers that, we hope, will provide inspiration for future work in this area.